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10.1016/j.biopha.2018.05.112 115 XuL.XiaH.NiD.HuY.LiuJ.QinY.et al (2020)

However, such differences appear to lessen after menopause, with postmenopausal women showing the least metabolic benefit, likely due to hormonal and BC changes [139, 140]

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FIGURE 1 Dysregulation of the IGF-1 signaling pathway has been implicated in a variety of aging-related diseases including muscle disease, cardiovascular diseases (CVDs), neurodegenerative diseases, metabolic diseases, and cancer (Zha and Lackner, 2010